4-Methyl-alpha-(4-methylphenyl)benzeneacetic acid → Benzeneacetic acid, 4-methyl-alpha-(4-methylphenyl)-, methyl ester

HRID 650523

반응식

HRID 650523 반응식
[C:1]1([CH3:18])[CH:6]=[CH:5][C:4]([CH:7]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.Cl.[CH3:20]O>CO>[C:14]1([CH3:17])[CH:13]=[CH:12][C:11]([CH:7]([C:4]2[CH:5]=[CH:6][C:1]([CH3:18])=[CH:2][CH:3]=2)[C:8]([O:10][CH3:20])=[O:9])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 303144-Methyl-alpha-(4-methylphenyl)benzeneacetic acidHCID 21893726Hydrochloride methanol

생성물 1

HCID 6452857Benzeneacetic acid, 4-methyl-alpha-(4-methylphenyl)-, methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of di-p-tolylacetic acid (4.90 g, 20.4 mmol) in methanol was treated with sat'd HCl/MeOH solution at room temperature. The mixture was stirred at room temperature (3 h). The solvent was removed in vacuo and the residue dissolved in dichloromethane and sodium bicarbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (21). The crude product was used directly.

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved in dichloromethane
  3. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
  4. washthe combined organic extracts were washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-457f78703e844a13b2f9a4ea3ef6e8db
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274583B1

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