Catechol → 4-Bromocatechol
반응식
[C:1]1([C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[OH:2].[Br-:9].[Br-].O1CCOCC1>CCOCC>[Br:9][C:6]1[CH:5]=[C:3]([OH:4])[C:1](=[CH:8][CH:7]=1)[OH:2]참가 물질
4
실험 절차
Catechol (11.0 g; 0.100 mol) is dissolved in 50 ml of ether and 29 g of freshly-prepared dioxane dibromide (Yanovskaya, Terent′ev and Belsn′kii), J. Gen. Chem. Vol. 22:1594 (1952)) is added slowly as a solution in 50 ml of ether. The organic solution is washed with water (3 times) and dried over MgSO4. The solvent is removed under reduced pressure to yield 4-bromocatechol as a red-brown oil. 1H NMR δ 5.52 (s, 1), 5.70 (s, 1), 6.74 (d, 1, J=8.74 Hz), 6.92 (dd, 1, J=8.3, 2.3 Hz), and 7.01 ppm (d, 1, J=2.6 Hz).
후처리
- washThe organic solution is washed with water (3 times)
- dry with materialdried over MgSO4
- customThe solvent is removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-7bf87f8b61204513b2f5c3656818076f
- 출처 데이터셋
- uspto-grants-2001_08
- 특허 번호
- US06274600B1
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