Benzene → 2-Pyrrolidinone, 5-phenyl-

HRID 650652노트

반응식

HRID 650652 반응식
C(O[CH:4]1[NH:9][C:7](=[O:8])[CH2:6][CH2:5]1)C.S(=O)(=O)(O)O.[CH:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([CH:4]2[NH:9][C:7](=[O:8])[CH2:6][CH2:5]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 241BenzeneHCID 1118Sulfuric AcidHCID 35805555-Ethoxy-2-pyrrolidinone

생성물 1

HCID 956722-Pyrrolidinone, 5-phenyl-수율 100%

실험 절차

At 0° C., 6.45 g of γ-ethoxy-γ-butyrolactam and 50 ml of concentrated sulphuric acid were charged initially, and 18.8 ml of benzene were added. After thawing, the mixture was stirred at room temperature for 4 days. For work-up, the mixture was poured onto ice, extracted three times with ethyl acetate and the combined extracts were washed once with water and once with saturated aqueous sodium chloride solution, dried and evaporated. 8.1 g (100% of theory) of γ-phenyl-γ-butyrolactam were obtained.

후처리

  1. additionFor work-up, the mixture was poured onto ice
  2. extractionextracted three times with ethyl acetate
  3. washthe combined extracts were washed once with water and once with saturated aqueous sodium chloride solution
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-8a49c0e611f346a5a0f65718dc975656
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274613B1

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