(R)-2-azido-1-benzylethylamine → (2R)-3-Phenylpropane-1,2-diamine

HRID 650677노트

반응식

HRID 650677 반응식
[N:1]([CH2:4][C@H:5]([NH2:13])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]([NH2:13])[CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

4

반응물 1

HCID 14802497(R)-2-azido-1-benzylethylamine

생성물 1

HCID 12699299(2R)-3-Phenylpropane-1,2-diamine수율 103.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A sample of the compound from step 3d (1.2 g, 6.8 mmole) was hydrogenated (4 atm) in ethanol over 1.2 g of 10% Pd/C for 21.5 hours at room temperature. The mixture was filtered to remove the catalyst, and the solvent was removed to afford the title compound (1.055 g). MS m/z (M+H)+: 151, MS m/z (M+NH4)+: 168.

후처리

  1. customfor 21.5 hours
  2. customat room temperature
  3. filtrationThe mixture was filtered
  4. customto remove the catalyst
  5. customthe solvent was removed

출처 및 근거

ORD 기록
ord-0e6fad3b9b6d48e99aba96743faa0b11
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06274715B1

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