Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentanal → methyl (1RS, 3RS)-cis-1-butyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentanal | HCID 8063 | — |
| 반응물 | methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride | HCID 2827264 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl (1RS, 3RS)-cis-1-butyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate hydrochloride | HCID 86741020 | 53% |
반응 단계
A mixture of DL-tryptophan methyl ester hydrochloride (30.49 g), n-valeraldehyde (12.4 g) and methanol (400 ml) is refluxed for 48 hours and then concentrated to about 1/5 volume. After cooling, the precipitates are separated by filtration and recrystallized from methanol to give methyl (1RS, 3RS)-cis-1-butyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate hydrochloride (20.5 g, 53%), m.p. 218° C. (decomp.) The hydrochloride thus obtained is treated with aqueous ammonia and recrystallized from diisopropyl ether-isopropanol to give the corresponding free base, m.p. 85°-87° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04612317 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-ff85d55b0bb44c4a897f042a092c8404 |
| 출처 메모 | uspto-grants-1986_09 |