Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butanal → methyl (1RS, 3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butanal | HCID 261 | — |
| 반응물 | methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride | HCID 2827264 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl (1RS, 3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate hydrochloride | HCID 86741021 | 38.5% |
반응 단계
A mixture of DL-tryptophan methyl ester hydrochloride (33 g), n-butyraldehyde (21.0 g) and methanol (450 ml) is refluxed for 48 hours. After the reaction, the reaction mixture is concentrated to about 1/3 in volume and allowed to stand. The precipitated crystals are collected by filtration and recrystallized from methanol to give methyl (1RS, 3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate hydrochloride (15.4 g, 38.4%) as colorless prisms, m.p. 205°-207° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04612317 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-867da906609240f199ae86d2289c2afe |
| 출처 메모 | uspto-grants-1986_09 |