Phosgene → N-methyl-N-(oxan-4-yl)carbamoyl chloride

HRID 650874

반응식

HRID 650874 반응식
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][NH:6][CH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1.C(N(CC)CC)C>>[CH3:5][N:6]([CH:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1)[C:1]([Cl:4])=[O:2]

참가 물질

4

반응물 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 69919504-(Methylamino)tetrahydro-2H-pyran

생성물 1

HCID 21709910N-methyl-N-(oxan-4-yl)carbamoyl chloride

실험 절차

248 g (2.5 mol) of phosgene, 96 g (0.83 mol) of N-methyl-N-(tetrahydro-2H-pyran-4-yl)amine and 84 g (0.83 mol) of triethylamine were reacted by the method of the process described in Intermediate 1.2. Yield 108 g. 1H NMR (250 MHz, in CDCl3): δ=1.60-1.95 (m, 4H), 2.94 and 3.01 (2 s, together 3H), 3.35-3.55 (rm, 2H), 3.95-4.10 (m, 2H), 4.27-4.46 (m, 1H).

출처 및 근거

ORD 기록
ord-caaf391666dc4bf88eab3ccb9cad41de
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06277790B1

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