Ethanol → 3-Amino-6-chloro-2-(3-methylbenzoyl)-1H-indole

HRID 651010

반응식

HRID 651010 반응식
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4](C(OCC)=O)[C:3]=1[C:17](=[O:25])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1.C([O-])([O-])=O.[K+].[K+].CCO>O>[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:17](=[O:25])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 11430Potassium CarbonateHCID 183680433-Amino-6-chloro-2-(3-methylbenzoyl)-1-(ethoxycarbonyl)indole

생성물 1

HCID 183678773-Amino-6-chloro-2-(3-methylbenzoyl)-1H-indole수율 84%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of ethyl 3-amino-6-chloro2-(3-methylbenzoyl)-1H-indole-1-caboxylate (step 1, 6.4 g, 18 mmol), K2CO3 (6.3 g, 45 mnmol) , EtOH (50 ml) and water (30 ml) was heated at reflux temperature for 20 h. The mixture was concentrated, and then water (30 ml) was added to the residue. The resulting mixture was extracted with dichloromethane (80 ml×2) and the combined extracts were dried (MgSO4). Removal of solvent gave 4.3 g (84%) of brown amorphous solids.

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 20 h
  3. concentrationThe mixture was concentrated
  4. additionwater (30 ml) was added to the residue
  5. extractionThe resulting mixture was extracted with dichloromethane (80 ml×2)
  6. dry with materialthe combined extracts were dried (MgSO4)
  7. customRemoval of solvent

출처 및 근거

ORD 기록
ord-78ad45ccc9a54c70a1c8741eceb8479b
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06277878B1

연결된 노트

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