Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-din-octanoyloxy-2-propoxymethyl)guanine → 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-din-octanoyloxy-2-propoxymethyl)guanine | HCID 136332157 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine | HCID 136332159 | 63.2% |
반응 단계
A solution of 0.969 g of N2 -(4-methoxyphenyldiphenylmethyl)-9-(1,3-di-n-octanoyloxy-2-propoxymethyl)guanine in 40 ml of glacial acetic acid plus 10 ml of water was stirred at 75° C. for 3 hours. The solution was then concentrated and the residue chromatographed over silica gel eluting with 1:15 methanol:methylene chloride to give a white solid. The product was recrystallized from methanol to afford 0.385 g of 9-(1,3-di-n-octanoyloxy-2-propoxymethyl)guanine, m.p. 165°-166° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04612314 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-26c19f5cba6e4a4587b94939921dde64 |
| 출처 메모 | uspto-grants-1986_09 |