Ethanol → 8-Cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid mesylate

HRID 651276노트

반응식

HRID 651276 반응식
[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[CH3:30][S:31]([OH:34])(=[O:33])=[O:32].C(O)C>O>[S:31]([OH:34])(=[O:33])(=[O:32])[CH3:30].[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:14][CH2:15]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

참가 물질

5

반응물 3

HCID 702EthanolHCID 6395Methanesulfonic AcidHCID 9802884Pradofloxacin

생성물 1

HCID 867572658-Cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid mesylate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

250 mg (0.63 mmol) of 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are dissolved in 2 ml of water, and one equivalent of methanesulfonic acid is added. The solution is stirred at room temperature for 30 minutes and then poured onto 20 ml of ethanol. The resulting precipitate is filtered off with suction and then dried.

후처리

  1. filtrationThe resulting precipitate is filtered off with suction
  2. customdried

출처 및 근거

ORD 기록
ord-afbf416cd71b40c1b556d1d0b461d36a
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06278013B1

반응 노트

불러오는 중…