Hydrogen Peroxide → (S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

HRID 651309노트

반응식

HRID 651309 반응식
[C:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])#[N:2].[OH:18]O>C1COCC1>[OH:18][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])=[C:3]([CH:4]=1)[C:1]#[N:2]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 53923893(S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylboronic acid

생성물 1

HCID 54230638(S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of compound 47 (3.00 g, 0.014 mol), hydrogen peroxide (30% w/v, 150 ml) and THF (200 ml) was heated under reflux for 3 h. The water/THF mixture was removed in vacuo and the oily residue was dissolved in diethyl ether and washed with water. The ether was dried (MgSO4) and evaporated in vacuo to give a viscous, fawn oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 h
  3. customThe water/THF mixture was removed in vacuo
  4. dissolutionthe oily residue was dissolved in diethyl ether
  5. washwashed with water
  6. dry with materialThe ether was dried (MgSO4)
  7. customevaporated in vacuo
  8. customto give a viscous, fawn oil

출처 및 근거

ORD 기록
ord-0561124ad43a4234a3c2bfac3e237389
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06278028B1

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