Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl alpha-oxobenzenebutanoate → Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl alpha-oxobenzenebutanoate | HCID 562087 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Toluene methanol | HCID 21867641 | — |
| 생성물 | Ethyl 2-hydroxy-4-phenylbutyrate, (+-)- | HCID 4092621 | — |
반응 단계
The general procedure described in Example B1 is repeated, with the following modifications to the reaction conditions: ethyl-4-phenyl-2-oxobutyrate (substrate): 0.352 g (1.7 mmol); solvent: 10 ml of toluene/methanol (1:1); hydrogen: 50 bar, temperature: 50° C.; reaction time: 19 hours. The conversion is 100%, ee: 44% (R).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE037344E1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-2a15d83e4c9a44eea74e25d3e9238d39 |
| 출처 메모 | uspto-grants-2001_08 |