Methanesulfonic Acid → p-Acrylamidomethylphenethyl chloride

HRID 65139

반응식

HRID 65139 반응식
[CH2:1]([Cl:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([NH:12][C:13](=[O:16])[CH:14]=[CH2:15])O.CS(O)(=O)=O>>[C:13]([NH:12][CH2:10][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][CH2:1][Cl:9])=[CH:4][CH:5]=1)(=[O:16])[CH:14]=[CH2:15]

참가 물질

4

반응물 3

HCID 6395Methanesulfonic AcidHCID 13543N-MethylolacrylamideHCID 2314961-Chloro-2-phenylethane

생성물 1

HCID 20235265p-Acrylamidomethylphenethyl chloride수율 75%

반응 조건

온도
15 °C

실험 절차

70 parts (0.5 mole) of phenethyl chloride and 51.5 parts (0.51 mole) of N-methylolacrylamide are stirred, in succession, into 300 parts by volume of methanesulfonic acid which has been cooled to 15° C. Stirring is continued for 6 hours at from 15° to 20° C., and hydrolysis is effected by adding 1,500 parts of crushed ice. After the ice has thawed, the product is filtered off and dried in the air to give 84 parts (yield: 75%) of crude p-acrylamidomethylphenethyl chloride, which is recrystallized from methyl alcohol to give a pure product of melting point 145°-147° C.

후처리

  1. customis continued for 6 hours at from 15° to 20° C., and hydrolysis
  2. additionby adding 1,500 parts of crushed ice
  3. filtrationthe product is filtered off
  4. customdried in the air

출처 및 근거

ORD 기록
ord-a09ae66e3614410880f3d764cf2e144f
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04612392

연결된 노트

불러오는 중…