4-Methylbenzoyl Chloride → N'-[(4-methylphenyl)carbonyl]-3-nitrobenzohydrazide

HRID 651396

반응식

HRID 651396 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([NH:9][NH2:10])=[O:8])([O-:3])=[O:2].[C:14]1([CH3:23])[CH:19]=[CH:18][C:17]([C:20](Cl)=[O:21])=[CH:16][CH:15]=1>N1C=CC=CC=1>[CH3:23][C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:10][NH:9][C:7](=[O:8])[C:6]2[CH:11]=[CH:12][CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[O:21])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 134054-Methylbenzoyl ChlorideHCID 32914983-Nitrobenzohydrazide

생성물 1

HCID 4506110N'-[(4-methylphenyl)carbonyl]-3-nitrobenzohydrazide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 3-nitrobenzhydrazide (2.16 g, 11.92 mmol) in pyridine (40 ml) cooled to 0° C. in an ice bath is added dropwise p-toluoyl chloride (1.94 g, 11.92 mmol). The mixture is allowed to warm to room temperature and stirred for 12 hours. The mixture is quenched with 350 mL of water and stirred for thirty minutes. The precipitate is filtered and dried in a vacuum oven to yield 1-[(4-methyl)benzoyl]-2-(3-nitrobenzoyl)hydrazine as a pale yellow solid. (2.94 g, 82%). 1H MMR (DMSOd6): δ 2.40 (s, 3H), 7.35 (d, 2H), 7.86 (d, 2H), 7.87 (t, 1H), 8.37 (d, 1H), 8.45 (d, 1H), 8.76 (s, 1H), 10.58 (s, 1H), 10.90 (s, 1H).

후처리

  1. customThe mixture is quenched with 350 mL of water
  2. stirringstirred for thirty minutes
  3. filtrationThe precipitate is filtered
  4. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-77427c6459dd44348c8490a76c1c2b90
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281217B1

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