4-Chloroaniline → LY 181984

HRID 651493

반응식

HRID 651493 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9]1([CH3:21])[CH:14]=[CH:13][C:12]([S:15]([N:18]=[C:19]=[O:20])(=[O:17])=[O:16])=[CH:11][CH:10]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:19]([NH:18][S:15]([C:12]2[CH:13]=[CH:14][C:9]([CH3:21])=[CH:10][CH:11]=2)(=[O:17])=[O:16])=[O:20])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 78124-ChloroanilineHCID 77703p-Toluenesulfonyl isocyanate

생성물 1

HCID 160725LY 181984수율 94.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

A solution of 6.25 g (49.00 mmoles) of 4-chloroaniline in 10 ml of methylene chloride was added to a solution of 9.85 g (49.95 mmoles) of p-toluenesulfonyl isocyanate in 75 ml of methylene chloride with stirring. The mixture became quite warm and a heavy white precipitate formed. An additional 100 ml of methylene chloride were added. The reaction mixture was stirred an additional 15 minutes, and the precipitate was recovered by filtration affording 15.0 g of the title product as a white solid. A small amount of the material was crystallized from diethyl ether to provide the title compound (87% yield) with a melting point of 174-176_C.

후처리

  1. temperatureThe mixture became quite warm
  2. customa heavy white precipitate formed
  3. stirringThe reaction mixture was stirred an additional 15 minutes
  4. filtrationthe precipitate was recovered by filtration

출처 및 근거

ORD 기록
ord-1760152cf4e848c6a7a57f68ac077b82
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281240B1

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