Trifluoroacetic acid → Pyrrolo[3,2-c]pyridin-1-yl-acetic acid

HRID 651627노트

반응식

HRID 651627 반응식
C([O:5][C:6](=[O:17])[CH2:7][N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[CH:10]=[CH:9]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[N:8]1([CH2:7][C:6]([OH:17])=[O:5])[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[CH:10]=[CH:9]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 54447290Pyrrolo[3,2-c]pyridin-1-yl-acetic acid tert-butyl ester

생성물 1

HCID 18176302Pyrrolo[3,2-c]pyridin-1-yl-acetic acid수율 150.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of pyrrolo[3,2-c]pyridin-1-yl-acetic acid tert-butyl ester (0.44 g, 1.89 mmol) in CH2Cl2 (10 mL) at 0° C. is added trifluoroacetic acid (1 mL). After 15 minutes, the solution is allowed to warm to room temperature and stirred for 18 hours. The reaction mixture is concentrated in vacuo and then azeotroped with toluene to give 0.5 g of the title compound as a residue (wet with excess TFA) which is used as is in the subsequent step

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customazeotroped with toluene

출처 및 근거

ORD 기록
ord-70f83433f2d34839bb2a66a629b56a34
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281227B1

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