Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(S)-Amino-1-(1-chloro-isoquinolin-7-ylmethyl)-pyrrolidin-2-one hydrochloride → 5'-Chloro-[2,2']bithiophenyl-5-sulfonic acid [1-(1-chloro-isoquinolin-7-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(S)-Amino-1-(1-chloro-isoquinolin-7-ylmethyl)-pyrrolidin-2-one hydrochloride | HCID 20680708 | — |
| 반응물 | 5'-Chloro-2,2'-bithiophene-5-sulfonyl chloride | HCID 22017280 | — |
| 생성물 | 5'-Chloro-[2,2']bithiophenyl-5-sulfonic acid [1-(1-chloro-isoquinolin-7-ylmethyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide | HCID 86757282 | — |
반응 단계
The title compound is prepared as described in EXAMPLE 56, Part A using 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride and 3-(S)-amino-1-(1-chloro-isoquinolin-7-ylmethyl)-pyrrolidin-2-one hydrochloride as starting material. The crude product is purified by column chromatography eluting with 5% MeOH/CH2Cl2 to give the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06281227B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-d77f1cdf0b5747cea8c37de410ddb71e |
| 출처 메모 | uspto-grants-2001_08 |