Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl carbamate | HCID 12136 | — |
| 반응물 | Ethyl oxoacetate | HCID 70211 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate | HCID 20233481 | 64.9% |
반응 단계
A solution of 17.3 g (0.169 mole) of ethyl glyoxylate and 23.0 g (0.152 mole) of benzyl carbamate in 250 ml of toluene was heated under reflux for 6 hours, with removal of water using a Dean-Stark trap. The resulting reaction mixture was concentrated in vacuo, and diethyl ether was added to the residue. The mixture was filtered, and the diethyl ether solution was evaporated in vacuo to give 25.0 g of ethyl 2-(benzyloxycarbonylamino)-2-(hydroxy)acetate as a sticky solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04613462 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-302a40ecef4448ebbe1ad41a616bb359 |
| 출처 메모 | uspto-grants-1986_09 |