L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid

HRID 651857

반응식

HRID 651857 반응식
N[C@H](C(O)=O)CC[C:5]([OH:7])=[O:6].[CH3:11][N:12]([C:26]1[CH:27]=[CH:28][C:29](C(N[C@H](C(O)=O)CCC(O)=O)=O)=[CH:30][CH:31]=1)[CH2:13][C:14]1[CH:15]=[N:16][C:17]2[N:23]=[C:22]([NH2:24])[N:21]=[C:20]([NH2:25])[C:18]=2[N:19]=1>>[NH2:24][C:22]1[N:21]=[C:20]([NH2:25])[C:18]2[C:17](=[N:16][CH:15]=[C:14]([CH2:13][N:12]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:5]([OH:7])=[O:6])[CH3:11])[N:19]=2)[N:23]=1

참가 물질

3

반응물 2

HCID 33032L-Glutamic AcidHCID 126941Methotrexate

생성물 1

HCID 70031183[[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid

실험 절차

The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.

후처리

  1. customThe yield of I obtained

출처 및 근거

ORD 기록
ord-39cc6343f5f141b9a3665e4ee56b3657
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281376B1

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