참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzyl Alcohol | HCID 244 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 2-Chloropropionic acid | HCID 11734 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 생성물 | 2-(Benzyloxy)propanoic acid | HCID 245987 | — |
반응 단계
An alternate method for the preparation of ether compounds corresponding to Formula I (R=alkyl, phenylalkyl) follows. Sodium metal (about 12 g) was added cautiously to a stirred cold (ice bath) portion (250 mL) of benzyl alcohol. After most of the sodium metal had dissolved, the reaction was heated to 150° C. 2-Chloropropionic acid (27.2 g, 0.25 mole) was added dropwise in 35 mL of benzyl alcohol and the resulting mixture heated on additional 3 hours. Concentration in vacuo gave crude 2-benzyloxypropionic acid which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04613600 |
|---|
| 출처 데이터셋 | uspto-grants-1986_09 |
|---|
| ORD ID | ord-fe9164041aa440dc9fdedea83fb7fb30 |
|---|
| 출처 메모 | uspto-grants-1986_09 |
|---|
