Allylamine → HCID 13747166, 화합물
반응식
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>O>[CH2:12]([NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[CH:9]=[N:10][NH:11][C:3]=12)[CH:13]=[CH2:14]참가 물질
4
실험 절차
A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (1.0 g, 0.006 mole) and allylamine (60 g) in water (100 ml) was heated under reflux for 12 days. On cooling the reaction mixture was evaporated to dryness, basified to pH8 with 10% sodium carbonate solution and the resulting solid filtered off. Recrystallisation from chloroform/pentane gave the product as white solid (1.0 g). m.p. 172°-174° C.
후처리
- temperaturewas heated
- temperatureunder reflux for 12 days
- temperatureOn cooling the reaction mixture
- customwas evaporated to dryness
- filtrationthe resulting solid filtered off
- customRecrystallisation from chloroform/pentane
출처 및 근거
- ORD 기록
- ord-8ceafe762bf746c1b5531cc156e2df43
- 출처 데이터셋
- uspto-grants-1987_06
- 특허 번호
- US04670432
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