Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | o-Chlorophenylacetic acid | HCID 17124 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(2-Chlorophenyl)-3-dimethylaminoprop-2-enal | HCID 54209358 | — |
반응 단계
73 g of dimethylformamide are cooled to -50° C. 92 g of phosphorus oxychloride are added dropwise, followed by 34.2 g of 2-chlorophenylacetic acid, and the reaction mixture is stirred at room temperature for 30 minutes. It is then heated at 70°-80° C. for 5 hours 30 minutes. The reaction mixture is rendered alkaline with potassium carbonate, 200 ml of toluene are added and the mixture is heated in a water bath for 1 hour.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04613603 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-9460d22982ec49918395afe4446371b9 |
| 출처 메모 | uspto-grants-1986_09 |