Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Glycine ethyl ester | HCID 12176 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 4-[14-(Trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride | HCID 20198230 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Ethyl 4-[14-(trimethylsilyl)tetradecylamino]hippurate | HCID 20198242 | — |
반응 단계
A solution of 20 g. 4-[14-(trimethylsilyl)tetradecylamino]benzoyl chloride hydrochloride in 100 ml. dioxane is added to 4.9 g. freshly prepared ethyl glycinate in 300 ml. of methylene chloride containing 1 g. of 4-(dimethylamino)pyridine and 10 ml. of triethylamine. After 16 hours at room temperature the reaction is refluxed for 2 hours, cooled and filtered. The mother liquor is extracted with water and 10% hydrochloric acid. The solution is dried and concentrated in vacuo to an amber liquid. A sample is chromatographed on silica, appropriate fractions are pooled and evaporated to yield a solid which is recrystallized to a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04670421 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-6b5996995f4e4a588ac5b7b2229113ed |
| 출처 메모 | uspto-grants-1987_06 |