참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Acetylthiourea | HCID 2723593 | — |
| 반응물 | Potassium cyanate | HCID 11378442 | — |
| 반응물 | 1-(4-Pyridyl)-1-bromo-2-butanone | HCID 20199218 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Ethyl-5-pyridin-4-yl-2(3H)thiazolone | HCID 20145016 | — |
반응 단계
1-(4-Pyridyl)-1-bromo-2-butanone (28.8 g, 0.1 mol) and 1-acetyl-2-thiourea (13.0 g, 0.11 mol) are combined in 200 ml absolute ethanol and refluxed 24 hours. The solvent is evaporated and the residue is purified by chromatography. The thiol is mixed with (8.1 g, 0.1 mol) potassium cyanate and 0.2 mol 10% aqueous hydrochloric acid. The mixture is heated to 80° C. for 15 minutes, then cooled. The acid is adjusted to ph=6.5 with solid sodium bicarbonate which causes the product to precipitate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04670450 |
|---|
| 출처 데이터셋 | uspto-grants-1987_06 |
|---|
| ORD ID | ord-59335595239343ebbaf7e4fe817cfef8 |
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| 출처 메모 | uspto-grants-1987_06 |
|---|
