Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzaldehyde → Phthalimidoamlodipine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzaldehyde | HCID 6996 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 반응물 | Ethyl 4-(2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy)-3-oxobutanoate | HCID 9840027 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Phthalimidoamlodipine | HCID 9871958 | — |
반응 단계
Methyl 3-aminocrotonate (72.2 g; 0.627M) and 2-chlorobenzaldehyde (88.1 g; 0.627M) were added to a solution of ethyl 4-(2-phthalimidoethoxy)acetoacetate (200 g; 0.627M) in isopropanol (1 liter) and the mixture was heated under reflux for 20 hours. The isopropanol was evaporated under reduced pressure and replaced by acetic acid (1 liter). After granulation at 10° the solid was collected and slurried in methanol (300 ml). The solid was collected by filtration and dried in vacuo at 50° to afford the title compound, yield 84.4 g, m.p. 146°-147°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04670449 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-a4ce0027ed954f5eafb3d35b6c7d99f5 |
| 출처 메모 | uspto-grants-1987_06 |