Ammonia → 5-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

HRID 652095노트

반응식

HRID 652095 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22](OCC)=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH3:30]>>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:27]=[CH:28][CH:29]=2)[O:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17]2[NH:21][N:20]=[C:19]([C:22]([NH2:30])=[O:23])[N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 178470502HCID 178470502, 화합물

생성물 1

HCID 1785138585-[4-[3-(1-Piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxamide

실험 절차

A suspension of ethyl 5-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxylate (867 mg) in 0.88 ammonia (25 ml) was stirred at room temperature for 18 h. The mixture was evaporated and the residual solid was washed with boiling methanol to leave the title compound as a white solid (255 mg) m.p. 212°-4° dec.

후처리

  1. customThe mixture was evaporated
  2. washthe residual solid was washed with boiling methanol

출처 및 근거

ORD 기록
ord-14c83efbb5a6445a914eda5e07f698f2
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670448

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