Methanol → Boc-Phe-Gly-OH

HRID 652379노트

반응식

HRID 652379 반응식
[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16]CC1C=CC=CC=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CO>[Pd].CC(O)=O>[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:2]([C:10]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 15601613HCID 15601613, 화합물

생성물 1

HCID 7014899Boc-Phe-Gly-OH수율 92.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

Boc-Phe-Gly-OBzl (6.2 g, 15 mmole) was suspended in the mixtured solvent of MeOH (80 ml) and AcOH (30 ml), and then H2 gas was passed through the solution in the presence of Pd-C for 4 hours. Pd-C was removed by filtration, and the solvent was distilled off. The thus-obtained residue was recrystalized two times with AcOEt/n-hexane to obtain the object product (4.49 g, 92.8%).

후처리

  1. customPd-C was removed by filtration
  2. distillationthe solvent was distilled off
  3. customThe thus-obtained residue was recrystalized two times with AcOEt/n-hexane

출처 및 근거

ORD 기록
ord-775688068557490fb481461376de20d4
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04670540

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