Pyridine, 3-(4-aminobutyl)- → 8-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyl)butyl]octanamide

HRID 652475노트

반응식

HRID 652475 반응식
[C:1]([C:4]1[CH:20]=[CH:19][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)=[C:6]([CH2:21][CH2:22][CH3:23])[C:5]=1[OH:24])(=[O:3])[CH3:2].[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][CH2:32][CH2:33][CH2:34][NH2:35])[CH:26]=1>>[C:1]([C:4]1[CH:20]=[CH:19][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:35][CH2:34][CH2:33][CH2:32][CH2:31][C:27]2[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=2)=[O:18])=[C:6]([CH2:21][CH2:22][CH3:23])[C:5]=1[OH:24])(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 137538758-(4-Acetyl-3-hydroxy-2-propylphenoxy)octanoic acid

생성물 1

HCID 139127848-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyl)butyl]octanamide

실험 절차

8-(4-Acetyl-3-hydroxy-2-propylphenoxy)octanoic acid was allowed to react with 3-pyridine butanamine according to procedure A and the product was purified by high performance liquid chromatography (HPLC) to give 8-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyl)butyl]octanamide, the title compound, mp 48°-51° (from ether-hexane) in 83% yield.

후처리

  1. customthe product was purified by high performance liquid chromatography (HPLC)

출처 및 근거

ORD 기록
ord-88a70e5beb3f4bb8859935641c681836
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04672066

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