Potassium Carbonate → Ethyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoate

HRID 652505노트

반응식

HRID 652505 반응식
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([OH:11])[CH:5]=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].Br[CH2:16][CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:22]([O:21][C:19](=[O:20])[CH2:18][CH2:17][CH2:16][O:11][C:6]1[CH:5]=[CH:4][C:3]([C:12](=[O:14])[CH3:13])=[C:2]([OH:1])[C:7]=1[CH2:8][CH2:9][CH3:10])[CH3:23]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 27751982',4'-Dihydroxy-3'-propylacetophenone

생성물 1

HCID 14330004Ethyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoate수율 55.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2.91 g of 1-(2,4-dihydroxy-3-propylphenyl) ethanone, 2.91 g of ethyl 4-bromobutyrate and 3.1 g of anhydrous potassium carbonate in 35 ml of anhydrous dimethyl formamide was stirred and heated at 75° for 12 hours. The solvent was removed in vacuo, the residue was treated with water and the product was extracted with ethyl acetate. The dried (over magnesium sulfate) extract was concentrated in vacuo and the crude product was purified by chromatography on 200 g of silica gel. Elution with 5% ethyl acetate-toluene gave 2.55 g (54% yield) of 4-(4-acetyl-3-hydroxy-2-propylphenoxy) butanoic acid ethyl ester, the titled compound, as an oil.

후처리

  1. temperatureheated at 75° for 12 hours
  2. customThe solvent was removed in vacuo
  3. additionthe residue was treated with water
  4. extractionthe product was extracted with ethyl acetate
  5. dry with materialThe dried (over magnesium sulfate)
  6. extractionextract
  7. concentrationwas concentrated in vacuo
  8. customthe crude product was purified by chromatography on 200 g of silica gel
  9. washElution with 5% ethyl acetate-toluene

출처 및 근거

ORD 기록
ord-04847d2dee834fa58c1c5563c54d8657
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04672066

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