Hydrochloric Acid → Levamisole

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A mixture containing 82.5 g of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (0.26 mol), 445 ml of water, 27.3 ml. sodium hydroxide 19.5 molar aqueous solution (0.53 mol) and 120.38 g of tetramisole hydrochloride (0.5 mol) was warmed up to 40° C. The warmed homogeneous mixture was adjusted to pH 4.2 with hydrochloric acid and cooled at 15° C. After 16 hours the precipitate was filtered off, washed and dried under vacuo at 50° C., yielding 127.44 g of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield=97.7%) αD20 =-63.7° (c5, 1N HCl); mp. 127.5°-128.3° C.

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