Hydrochloric Acid → Levamisole

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A mixture containing 11.39 kg of L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (35.9 mol), 61 l of water, 3.77 l sodium hydroxide 19.5 molar aqueous solution (73.5 mol) and 16.61 kg of tetramisole hydrochloride (69 mol) was warmed up to 40° C. The homogeneous mixture was adjusted to pH 4.2 with hydrochloric acid and cooled at 15° C. After 18 hours the precipitate was filtered off, washed and dried under vacuo at 50° C., yielding 17.15 kg of levamisole.L-N-[(4-methoxyphenyl)sulfonyl]glutamic acid (salt) (yield: 95%); αD20 =65.1° (c5, 1N HCl); mp. 127.9°-129.4° C.

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