Water → 2-Benzo[b]furan-3-ylethylamine

HRID 652724

반응식

HRID 652724 반응식
[C:1]([CH2:3][C:4]1[C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=2[O:7][CH:8]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O>C(OCC)C>[O:7]1[CH:8]=[C:4]([CH2:3][CH2:1][NH2:2])[C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][C:6]1=2

참가 물질

5

반응물 3

HCID 962WaterHCID 2769401Benzofuran-3-acetonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 124208122-Benzo[b]furan-3-ylethylamine수율 79.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 3.97 g (0.025 mole) of 3-cyanomethylbenzo[b]furan in 200 mL of diethyl ether was slowly added to a refluxing suspension of 3.84 g (0.1 mole) of lithium aluminum hydride in 400 mL of ether. The reaction was heated 3 hrs., cooled and water was slowly added. The suspension was filtered through a pad of filter aid and the filtrate was evaporated to give 3.2 g of oily product. The hydrochloride salt has m.p. 183°-185° C.

후처리

  1. temperatureThe reaction was heated 3 hrs
  2. temperature, cooled
  3. filtrationThe suspension was filtered through a pad of filter aid
  4. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-1f3d942583b544f09bfff1984f071303
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04673680

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