Ammonia → 4-Bromo-2-methoxy-5-sulfamoylbenzoic acid

HRID 652762노트

반응식

HRID 652762 반응식
[NH3:1].[CH3:2][O:3][C:4]1[CH:12]=[C:11]([Br:13])[C:10]([S:14](Cl)(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>>[CH3:2][O:3][C:4]1[CH:12]=[C:11]([Br:13])[C:10]([S:14](=[O:16])(=[O:15])[NH2:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 221014544-Bromo-5-(chlorosulfonyl)-2-methoxybenzoic acid

생성물 1

HCID 221014104-Bromo-2-methoxy-5-sulfamoylbenzoic acid수율 85%

실험 절차

1,290 ml of 22° Be. ammonia is placed in a 3 liter flask fitted with an agitator and a thermometer. It is cooled, and 805 g of 2-methoxy-4-bromo-5-chlorosulphonyl-benzoic acid is added in stages between 0° and +10° C. The reaction medium is agitated for 1 hour at about +10° C. then the solution is filtered with charcoal. The filtrate is diluted with 300 ml of water and the acid precipitated by adding hydrochloric acid (density 1.18). The precipitate is drained, washed with water and dried in an oven at 50° C. 645 g (85%) of product is obtained, melting at 256° C.

후처리

  1. custom1,290 ml of 22° Be
  2. customfitted with an agitator
  3. temperatureIt is cooled
  4. filtrationthe solution is filtered with charcoal
  5. additionThe filtrate is diluted with 300 ml of water
  6. customthe acid precipitated
  7. additionby adding hydrochloric acid (density 1.18)
  8. washwashed with water
  9. customdried in an oven at 50° C

출처 및 근거

ORD 기록
ord-00566aa203d94461a72c086ba5e5b022
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04673686

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