참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Bromopyridine | HCID 7973 | — |
| 반응물 | 2,3-Dichloro-4-methoxybenzaldehyde | HCID 13015689 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol | HCID 13015690 | — |
반응 단계
29.3 g of 2-bromopyridine in 150 ml of dry THF is added to 75 ml of 2.6M n-butyllithium that was chilled to -65° C. 2,3-dichloro-4-methoxybenzaldehyde (38.0 g) is then added in 300 ml of THF and the reaction mixture allowed to come to room temperature. It is poured into H2O and the crystalline product filtered off, washed with ether and dried to give α-(2,3-dichloro-4-methoxyphenyl)-2-pyridinemethanol, mp 174°-176° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04673746 |
|---|
| 출처 데이터셋 | uspto-grants-1987_06 |
|---|
| ORD ID | ord-e18c891711e349d7ba5be4862e39b7f1 |
|---|
| 출처 메모 | uspto-grants-1987_06 |
|---|
