Sinapic acid → Ethyl 3,5-dimethoxy-4-hydroxycinnamate

HRID 652956

반응식

HRID 652956 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:15][CH3:16])[C:13]=1[OH:14])[CH:6]=[CH:7][C:8]([OH:10])=[O:9].S(=O)(=O)(O)O.[CH2:22](O)[CH3:23]>O>[CH3:16][O:15][C:12]1[CH:11]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:13]=1[OH:14])[CH:6]=[CH:7][C:8]([O:10][CH2:22][CH3:23])=[O:9]

참가 물질

4

반응물 2

HCID 10743Sinapic acidHCID 73950302Sulphuric acid ethanol

생성물 1

HCID 135424Ethyl 3,5-dimethoxy-4-hydroxycinnamate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In an argon atmosphere, 3.00 g (13.4 mmol) of 3,5-dimethoxy-4-hydroxycinnamic acid was suspended in a sulfuric acid - ethanol (1 : 115, 50 ml) solution. The suspension was refluxed for 5.5 hours. Water was added to the reaction solution, and the mixture was extracted with methylene chloride. The organic layer was washed with an aqueous solution of sodium hydrogen carbonate and concentrated under reduced pressure to give 3.34 g (13.24 mmol) of ethyl 3,5-dimethoxy-4-hydroxycinnamate.

후처리

  1. temperatureThe suspension was refluxed for 5.5 hours
  2. extractionthe mixture was extracted with methylene chloride
  3. washThe organic layer was washed with an aqueous solution of sodium hydrogen carbonate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-44042270d45241359e930c29414b599e
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04673684

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