2-Chloroethanol → Benzhydryl 2-chloroethyl ether

HRID 652961노트

반응식

HRID 652961 반응식
[Cl:1][CH2:2][CH2:3][OH:4].S(=O)(=O)(O)O.[CH:10](O)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1C=CC=CC=1>[Cl:1][CH2:2][CH2:3][O:4][CH:10]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 342-ChloroethanolHCID 1118Sulfuric AcidHCID 7037Benzhydrol

생성물 1

HCID 141724Benzhydryl 2-chloroethyl ether수율 100.1%

시약·촉매·용매 1

HCID 241Benzene용매2회

반응 조건

온도
50 °C

실험 절차

To a solution of 3.27 g of 2-chloroethanol in dry benzene (3.5 ml) was added 0.8 g of conc. sulfuric acid and the mixture was heated, under argon atmosphere, at 50° C. To the mixture was added slowly a solution of 5.0 g of benzhydrol in dry benzene (6.5 ml) and, after 30 minutes from the addition, the whole mixture was refluxed for 1.5 hours. After the mixture was allowed to cool, the benzene layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, to give 6.7 g of benzhydryl 2-chloroethyl ether.

후처리

  1. additionafter 30 minutes from the addition
  2. temperaturethe whole mixture was refluxed for 1.5 hours
  3. temperatureto cool
  4. washthe benzene layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-de20cc6f8a87461ca0fe015b58495983
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04673684

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