Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromo-3-chloropropane → 5-Chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Sodium amide | HCID 24533 | — |
| 반응물 | 2-(3,4-Dimethoxyphenyl)-3-methylbutanenitrile | HCID 89396 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-Chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile | HCID 619953 | — |
반응 단계
Alternatively, one may prepare compounds of the invention via the procedures of Scheme III. In the first step, a derivative of formula 6a (see Scheme II) is alkylated with a 1,3-dihalopropane using a strong base in a suitable aprotic solvent to produce a derivative of formula 21 (step 1). For example, 2-(3,4-dimethoxyphenyl)-2-isopropylacetonitrile is treated with sodium amide in toluene and 1-bromo-3-chloropropane to produce 2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)-acetonitrile (21).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04613606 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-48303057aabd4f9c89aab8dcf056d73b |
| 출처 메모 | uspto-grants-1986_09 |