2-Thiophenecarboxaldehyde → 2-[1-(Ethoxy)ethoxy]-3-(2-thienyl)propenal

HRID 653028

반응식

HRID 653028 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH2:8]([O:10][CH:11]([O:13][CH2:14][CH:15]=[O:16])[CH3:12])[CH3:9]>C1(C)C=CC=CC=1>[CH2:8]([O:10][CH:11]([O:13][C:14](=[CH:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH:15]=[O:16])[CH3:12])[CH3:9]

참가 물질

4

반응물 2

HCID 73642-ThiophenecarboxaldehydeHCID 13876797(1-Ethoxyethoxy)acetaldehyde

생성물 1

HCID 537286552-[1-(Ethoxy)ethoxy]-3-(2-thienyl)propenal수율 20.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Except to use a reaction time of 36 hours at ambient temperature, and to use toluene as eluant on chromatography, thiophene-2-carbaldehyde (3.1 ml., 3.74 g., 0.083 mol) and 2-[1-(ethoxy)ethoxy)acetaldehyde (4.0 g., 0.030 mol) were converted to instant title product as a yellow solid 1.39 g., crystallized from hexane, 109 mg.; 1H-nmr: 1.14 (t, 3H), 1.52 (d, 3H), 3.75 (m, 2H), 6.01 (q, 1H), 6.99 (s, 1H), 7.15 (m, 1H), 7.53 (m, 2H), 9.40 (s, 1H).

후처리

  1. customa reaction time of 36 hours
  2. customat ambient temperature

출처 및 근거

ORD 기록
ord-ab22ffc0f14e409ca90b230fb9a42b62
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04675186

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