Acetyl chloride → Methyl 2-Benzyloxy-2-methylpropionate

HRID 653040노트

반응식

HRID 653040 반응식
[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(=O)C>CO>[CH2:1]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([O:12][CH3:15])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 113445632-(Benzyloxy)-2-methylpropanoic acid

생성물 1

HCID 13716841Methyl 2-Benzyloxy-2-methylpropionate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Benzyloxy-2-methylpropionic acid (4.4 g., 0.0023 mol) was dissolved in 50 ml. of methanol treated with acetyl chloride (1.61 ml., 1.78 g., 0.0023 mol), stirred for 16 hours, stripped to an oil, taken up in 75 ml. ethyl acetate, washed 1×50 ml. saturated NaHCO3 and 1×50 ml. brine, dried over MgSO4 and stripped to yield purified title product as a second oil, 4.22 g.; 1H-nmr 1.5 (s, 6H), 3.8 (s, 3H), 4.5 (s, 2H), 7.3-7.5 (m, 5H).

후처리

  1. washethyl acetate, washed 1×50 ml
  2. dry with materialbrine, dried over MgSO4
  3. customto yield
  4. custompurified title product as a second oil, 4.22 g

출처 및 근거

ORD 기록
ord-32692ca7e0bc4a0d85e54c68f8d628d3
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04675186

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