Tetrahydrofuran → N-(6-trifluoromethylbenzothiazol-2-yl)-2,6-difluorobenzamide

HRID 653061

반응식

HRID 653061 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](Cl)=[O:5].[NH2:12][C:13]1[S:14][C:15]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:16]=2[N:17]=1.O1CCCC1>C(N(CC)CC)C>[F:25][C:22]([F:23])([F:24])[C:20]1[CH:19]=[CH:18][C:16]2[N:17]=[C:13]([NH:12][C:4](=[O:5])[C:3]3[C:2]([F:1])=[CH:10][CH:9]=[CH:8][C:7]=3[F:11])[S:14][C:15]=2[CH:21]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 874382,6-Difluorobenzoyl chlorideHCID 27359552-Amino-6-(trifluoromethyl)benzothiazole

생성물 1

HCID 13798346N-(6-trifluoromethylbenzothiazol-2-yl)-2,6-difluorobenzamide수율 78.2%

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
35 °C

실험 절차

At 0 to 5° C., 2,6-difluorobenzoyl chloride (1.77 g) was added dropwise to a solution composed of 2-amino-6-trifluoromethylbenzothiazole (2.18 g), tetrahydrofuran (30 ml) and triethylamine (1.1 g). The reaction mixture was stirred at 30 to 40° C. for 5 hours, and then tetrahydrofuran was evaporated. The solid residue was washed with water and recrystallized from ethanol to give the desired N-(6-trifluoromethylbenzothiazol-2-yl)-2,6-difluorobenzamide (2.8 g).

후처리

  1. customtetrahydrofuran was evaporated
  2. washThe solid residue was washed with water
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-af5269f2565d4bfc9aeed13fa9888872
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04675331

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