Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Phenylanthranilic Acid → 5-Chloro-3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Phenylanthranilic Acid | HCID 4386 | — |
| 반응물 | 5-Chloro-2-(phenylamino)benzoic acid | HCID 12369456 | — |
| 반응물 | Methyl 3-hydroxy-1-phenyl-1H-indole-2-carboxylate | HCID 54687160 | — |
| 생성물 | 5-Chloro-3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester | HCID 54734281 | — |
반응 단계
Prepared in a manner analogous to the multistep procedure described [P. Friedlander and K. Kunz, Chem. Ber., 55, 1597 (1922)] for the preparation of 3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester, with 5-chloro-2-(phenylamino)benzoic acid substituted for 2-(phenylamino)benzoic acid in the first step of the synthetic sequence. The final indole product was recrystallized from aqueous 2-methoxyethanol to yield analytically pure product, mp 170°-173° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04675332 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-d3bdd14ac4ed4593b0ece2902df6fd18 |
| 출처 메모 | uspto-grants-1987_06 |