Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 178425692, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Thiouracil | HCID 1269845 | — |
| 반응물 | 6-Methyl-3-pyridinecarboxaldehyde | HCID 10192566 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 178425692 | HCID 178425692 | 45.4% |
반응 단계
A mixture of 5 g (0.04 mol) of 2-methyl-5-formylpyridine, 5.29 g (0.04 mol) of 2-thiouracil and 50 ml of concentrated hydrochloric acid was heated overnight. The solution was neutralized with sodium bicarbonate. The organic material in the resulting precipitate was taken up in methanol which was then evaporated to give 4.53 g (45%) of 4-hydroxy-2-mercapto-5-[(6-methyl-3-pyridinyl)hydroxymethyl]pyrimidine [MS(m/e)250]. This compound (2 g) is treated with zinc-acetic acid as in Example 9 to give the same end product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04675406 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-b281c33505d3421fa4ef78bb81481455 |
| 출처 메모 | uspto-grants-1987_06 |