Nitric Acid → 1,2-Dichloro-3-nitro-5-(trifluoromethyl)benzene

HRID 65337

반응식

HRID 65337 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[Cl:8].S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:10])[F:11])[CH:5]=[C:6]([N+:18]([O-:20])=[O:19])[C:7]=1[Cl:8]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 94813,4-Dichlorobenzotrifluoride

생성물 1

HCID 27740301,2-Dichloro-3-nitro-5-(trifluoromethyl)benzene수율 18.1%

반응 조건

온도
95 °C

실험 절차

3,4-Dichloro-α,α,α-trifluorotoluene (862 g. 4.0 mols) is added to a stirred mixture of concentrated sulfuric acid (4400 g.) and nitric acid (3400 g.) at 35° C. The mixture is stirred 70 minutes at 95° C. and allowed to separate. The oil layer is washed once with water and twice with 5% sodium carbonate solution, dried, and fractionally distilled to give 3,4-dichloro-5-nitro-α,α,α-trifluorotoluene (188 g. 18%) b.p. 115°-118° C./15 mm, 88% pure.

후처리

  1. customto separate
  2. washThe oil layer is washed once with water and twice with 5% sodium carbonate solution
  3. customdried
  4. distillationfractionally distilled

출처 및 근거

ORD 기록
ord-cd3293f77b654d138e4f5d29bac0caf4
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04613360

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