Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-((Phenylmethoxy)carbonyl)-L-serine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-(Benzyloxycarbonyl)-L-serine | HCID 100310 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-((Phenylmethoxy)carbonyl)-L-serine methyl ester | HCID 6999535 | — |
반응 단계
N-CBZ-L-serine (25 g) was dissolved in 100 ml of dry N,N-dimethylformamide at 0° C. under argon. Triethylamine (2 e.g., 30 ml) and dimethylsulfate (20 ml) were added. The contents of the vessel were stirred overnight at room temperature and then poured into 500 ml of water and extracted with ethyl acetate (3×200 ml). The organic layer was washed with water and brine and dried with sodium sulfate. Rotary evaporation afforded an oil which crystallized after silica gel chromatography in pure ethyl ether. The structure of the product, N-CBZ-L-serine methyl ester, was confirmed by NMR spectroscopy.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04676989 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-49d76b88f95e44b78687b03e026d330d |
| 출처 메모 | uspto-grants-1987_06 |