Toluene → Methyl acetate hexane

HRID 653551

반응식

HRID 653551 반응식
[N+]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1S(N)(=O)=O)([O-])=[O:2].NCP(=O)(OC(C)C)[O:17][CH:18](C)C.[C:26]1([CH3:32])C=CC=CC=1>>[C:26]([O:17][CH3:18])(=[O:2])[CH3:32].[CH3:8][CH2:9][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 1385102-NitrobenzenesulfonamideHCID 13740526Dipropan-2-yl (aminomethyl)phosphonate

생성물 1

HCID 23449302Methyl acetate hexane

실험 절차

10 g (0.58 mole) of 2-nitrophenylsulfonamide are suspended in 20 ml of toluene and heated to reflux temperature. 17.0 g (0.087 mole) of diisopropyl aminomethylphosphonate are added dropwise to the hot solution. The reaction mixture is then boiled under reflux for 10 hours, cooled and evaporated. Chromatographing the residue over silica gel with a 4:1 methyl acetate/hexane mixture gives 1.6 g of 2-(di-i-propoxyphosphonylmethylamino)-phenylsulfonamide in the form of a yellow oil.

후처리

  1. temperatureheated
  2. temperatureto reflux temperature
  3. temperatureunder reflux for 10 hours
  4. temperaturecooled
  5. customevaporated

출처 및 근거

ORD 기록
ord-f0454959cd19471f87064f43432f0e9c
출처 데이터셋
uspto-grants-1987_06
특허 번호
US04677217

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