Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-(3-Chloro-2-methylph-enyl-thiomethyl)-2-imidazoline hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride | HCID 2760928 | — |
| 반응물 | 3-Chloro-2-methylbenzenethiol | HCID 14878236 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(3-Chloro-2-methylph-enyl-thiomethyl)-2-imidazoline hydrochloride | HCID 14878238 | — |
반응 단계
5.55 g (35 mmol) of 3-chloro-2-methyl-thiophenol, 5.43 g (35 mmol) of 2-chloromethyl-2-imidazoline hydrochloride and 5 g of potassium carbonate are stirred in 40 ml of ethanol at room temperature. After 25 h, the mixture is filtered and the filtrate is concentrated to dryness. The crude product is purified by column chromatography on silica gel. After the eluting agent has been stripped off, ethanolic hydrochloric acid is added to the residue and the product is precipitated by addition of ether. White crystals of melting point 208°-209° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05128361 |
| 출처 데이터셋 | uspto-grants-1992_07 |
| ORD ID | ord-8929725e1b2f4869a090178749328139 |
| 출처 메모 | uspto-grants-1992_07 |