Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-(2-Amino-1-hydroxypropyl)phenol | HCID 11099 | — |
| 반응물 | 1-(Isochroman-1-yl)propan-2-one | HCID 12777063 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(4-Hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]-1-propanol | HCID 19889960 | 72% |
반응 단계
An oily product was obtained in the same manner as in Example 1, using (isochroman-1-yl)acetone and 2-amino-1-(4-hydroxyphenyl)-1-propanol [J. Med. Chem., 14, 148 (1971)]. The product was dissolved in anhydrous methanol, and concentrated hydrochloric acid was added thereto. The solvent was evaporated off to give a hydrochloride. The hydrochloride was then washed with ether to give Compound 24 as crystals in a yield of 72%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05128369 |
| 출처 데이터셋 | uspto-grants-1992_07 |
| ORD ID | ord-309b8a8a7400410bb9a257c4a7f3f5cf |
| 출처 메모 | uspto-grants-1992_07 |