Methanol → Methyl 2-Amino-5-methylbenzoate

HRID 653705노트

반응식

HRID 653705 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17]O>>[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 762552-Amino-5-methylbenzoic acid

생성물 1

HCID 1201104Methyl 2-Amino-5-methylbenzoate수율 74%

실험 절차

A mixture of 2-amino-5-methyl benzoic acid (10 g) in methanol (50 ml) containing conc. sulfuric acid (5.5 ml) was heated for 19 hours under reflux. The solvent was distilled off, and the residue was dissolved in water. The solution was neutralized with an aqueous sodium hydroxide, followed by extraction with ethyl acetate. The organic layer was dried and concentrated to afford a pale brown oil (8.1 g, 74%).

후처리

  1. temperaturewas heated for 19 hours
  2. temperatureunder reflux
  3. distillationThe solvent was distilled off
  4. dissolutionthe residue was dissolved in water
  5. extractionfollowed by extraction with ethyl acetate
  6. customThe organic layer was dried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bc92e83984b842d8837982b28305a6a3
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128356

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