Triethylamine → Methyl 5-methyl-2-valerylaminobenzoate

HRID 653706

반응식

HRID 653706 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)Cl>[CH3:12][C:9]1[CH:10]=[CH:11][C:2]([NH:1][C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 1201104Methyl 2-Amino-5-methylbenzoate

생성물 1

HCID 19792094Methyl 5-methyl-2-valerylaminobenzoate수율 104.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 2-amino-5-methylbenzoate (8.1 g) and triethylamine (6.0 g) in methylene chloride (50 ml) was added dropwise, while stirring under ice-cooling, valeryl chloride (6.5 g). The reaction was allowed to stir for two hours, then the reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water, followed by drying. The solvent was evaporated to dryness to give a pale brown oil (12.8 g, 99%).

후처리

  1. temperaturecooling
  2. stirringto stir for two hours
  3. washthe reaction mixture was washed with an aqueous solution of sodium carbonate, dilute hydrochloric acid and water
  4. customby drying
  5. customThe solvent was evaporated to dryness

출처 및 근거

ORD 기록
ord-7352affd105141e995fc2529a0f1e185
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128356

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