4-Iodotoluene → Methyl 3-(4-methylphenyl)benzoate

HRID 653878

반응식

HRID 653878 반응식
I[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].I[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1>[Cu]>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 122074-IodotolueneHCID 69258Methyl 3-iodobenzoate

생성물 1

HCID 1394187Methyl 3-(4-methylphenyl)benzoate수율 34.9%

시약·촉매·용매 1

HCID 23978Copper촉매3회

실험 절차

To a stirred solution of 25.2 g of methyl 3-iodobenzoate and 21.0 g of 4-iodotoluene at 180°-190° under nitrogen was added 30.3 g of copper powder portionwise over 1 hour. When approximately one-third of the copper had been added, the reaction initiated and the temperature increased spontaneously to 240°. The mixture was allowed to cool to 210°, then was held at 210° during the addition of the remaining copper and for an additional hour. The mixture was allowed to cool to room temperature and was filtered employing benzene as solvent; the resulting filtrate was concentrated in vacuum to provide the crude product. Column chromatography on silica gel (elution=50-100% benzene/hexane) followed by distillation furnished 7.60 g of methyl 4'-methylbiphenyl-3-carboxylate [bp:114°-115° C. (0.025 torr)] as a colorless oil; NMR (200 MHz, CDCl3): δ 8.27 (br S, 1H); 7.99 (d, 1H); 7.77 (d, 1H); 7.50 (t, 1H); 7.39 (A2B2, 4H); 3.94 (s, 3H); 2.41 (s, 3H).

후처리

  1. temperaturethe temperature increased spontaneously to 240°
  2. temperatureto cool to 210°
  3. filtrationwas filtered
  4. concentrationthe resulting filtrate was concentrated in vacuum
  5. customto provide the crude product
  6. distillationColumn chromatography on silica gel (elution=50-100% benzene/hexane) followed by distillation

출처 및 근거

ORD 기록
ord-5df33059a34341cd8c4322dd400b5cbd
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05128355

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